Dextran is a complex branched glucan polysaccharide derived from the condensation of glucose. Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron is chiefly important to the human body because it is the main constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Also described as low viscous or low viscosity dextran, dextran 40 is prepared by acid hydrolysis and differential fractionation. Pollmann ds, smith je, stevenson js, schoneweis da, hines rh. It is only used to treat patients who cannot be adequately treated with oral iron supplements. Unnecessary or prolonged administration of iron may lead to iron overload and consequently the possibility of exogenous hemosiderosis. Briefly, mice were divided into 3 groups based on the dose of iron preparation in form of iron dextran hemadexsanbe, jakarta. Circulating iron dextran is dissociated by the reticuloendothelial system. The material injected may be a test substance as in determining allergic sensitivity or immunity to a disease, an anesthetic, a therapeutic drug, a nutrient in cases where intravenous feeding is necessary, blood, or blood plasma see blood transfusion blood transfusion. Iron dextran is used to treat iron deficiencies and iron deficiency anemia low red blood cells.
Iron dextran injection is commercially available as a ster. Some medications, such as imferon iron dextran and vistaril. Indicated for the prevention or treatment of baby pig anemia due to iron deficiency. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
Circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. Comparison of gleptoferron with iron dextran for anemia prevention in young pigs. Iron dextran formulations luitpold pharmaceuticals, inc. Iron dextran is a stable, clear brown solution available in 2 and 5ml ampuls and a 10ml multipledose vial. Iron dextran is a complex of ferric hydroxide and dextran in a colloidal solution. Iron dextran is an injectable form of iron used to treat irondeficiency anemia, a condition in which the blood doesnt have enough healthy red blood cells because of a deficiency of available iron. Each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0. Cosmofer low molecular weight mw iron dextran is a highly refined parenteral iron formulation, with a well documented safety profile39. For the prevention and treatment of iron deficiency. The piglets in group iii n 10 did not receive any iron till the age of 21 days. On day 21, they were treated with iron dextran 200mg fe 3.
This medicine is used to treat people who cannot take iron by mouth and have low levels of iron in the blood. This ed material has been downloaded from a licensed data provider and is not for distribution, except. Another nutritional supplement, iron dextran, targets. The type of iron in cosmofer is the same as that found naturally in the. Occupational exposure to iron dextran complex may occur during the production, formulation, packaging, or administration of the. Intramuscular versus subcutaneous administration of iron. Iron dextran definition of iron dextran by medical. Iron dextran complex canada sri 2009 and is available.
The trade data from india has not been released since november 2016, as an official government notification, dated 25. Iron dextran is absorbed from the injection site after intramuscular injection, for example, into the capillaries and the lymphatic system. Iron dextran may also be used for purposes not listed in. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Iron dextran is contraindicated for use in patients with anemia not associated with iron deficiency. Get iron dextran at best price with product specifications. To make it easier for users to find and install plugins, pathvisio 3 incorporates a plugin manager that connects to. Reserve for use only in patients with laboratoryconfirmed iron deficiency who are unable to take oral iron. Ive been looking for a plugin like this for quite some time and was hoping. Low mw iron dextran has been used in more than 75 million doses2 and is characterized by significantly less adverse events compared to high mw iron dextran 39 cosmofer solution for injection contains iron in a stable aqueous ironiii.
Circulating iron dextran is cleared from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. Transfer 25 mg of dose into 1cc syringe and inject into the 50cc bag of 0. The use of 5% dextrose as diluent is associated with increased incidence of local pain and phlebitis. Iron can be supplemented by mouth using various forms, such as ironii sulfate.
The second option is preparation such as iron dextran and iron. Iron dextran injection is commercially available as a sterile solution of iron dextran complex containing 5% iron and 20% dextran. Adverse events including life threatening associated with. Iron dextran is used to treat iron deficiencies and iron deficiency anemia low red blood cells iron dextran may also be used. As of 20, this field contains the consumer friendly descriptions for the ama cpt codes. Towards the complete picture maastricht university. Iron is critical for normal hemoglobin synthesis to maintain oxygen transport. It contains 50 mgiml of elemental iron, most of which is present in the ferric state. Dextran chains are of varying lengths from 3 to 2000 kilodaltons the polymer main chain consists of.
Iron is an important mineral and is a necessary component of red blood cells and their ability to carry. This medication is usually injected deep into the muscle of the buttock or slowly into a vein as directed by your doctor. Gleptoferron, a sterile aqueous colloidal solution of betaferric oxyhydroxide and dextran glucoheptonic acid, was compared with iron dextran for the prevention of fe deficiency anemia in young pigs. Adults, adolescents, and children weighing more than 15 kg. Some drugs, however, do interact, for example alendronate is strongly absorbed and the pi warnings in that context. Iron dextran side effects, dosage, interactions drugs.
Iron is used to make healthy red blood cells, which carry oxygen and nutrients through the body. Lmd dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran average mol. Last iv iron infusion about a year ago must use iron dextran infed causes dysrhytmia. Imiv dose is individualized and determined from a table of correlations between patients weight and hemoglobin see package insert. Dailymed lmd in dextrose dextran 40 injection, solution. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. Iron dextran definition of iron dextran by the free. I have decreased my dosage to 1 pill325 mg per day, eating red meat, and. Listing a study does not mean it has been evaluated by the u. Put on your gloves and insert the syringe into the tube. B complex combination goi with iron and folic acid preparations and also no to sustained release preparations dosage. Iron dextran article about iron dextran by the free. This is the most common and well studied soluble iron salt sold under brand names such as feratab, feriron, and slowfe.
This medication passes into breast milk and may have undesirable effects on a nursing infant. The number of electrons in each of irons shells is 2, 8, 14, 2 and its electron configuration is ar 3d 6 4s 2. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of. Ferrlecit sodium ferric gluconate complex in sucrose injection is a stable macromolecular complex used to replete and maintain the total body content of iron. A constant although small intake of iron in food is needed to replace erythrocytes that are. Patients receiving ferrlecit require periodic monitoring of hematologic and iron parameters hemoglobin, hematocrit, serum ferritin, and transferrin saturation. A history of drug allergy including multiple drug allergies andor the concomitant use of an ace inhibitor may increase the risk of anaphylactictype reactions. Cosmofer contains a combination of iron and dextran a long chain of sugar molecules. Erythropoiesis is optimized in chronic kidney disease by treatment with iron and erythropoiesisstimulating agents esas. Selected from data included with permission and ed by first databank, inc. Comparison of intravenous iron products available in canada iron dextran availability infuferr 50 mgml in 2 ml and 5 ml vials available in canada since 1997 contraindications hypersensitivity or precautions to product anemia unrelated to iron deficiency acute kidney infection concomitant use of oral iron products history.
It is in complex with gluconate, dextran, carbonyl iron, and other salts. Potential advantages of iv iron include direct iron delivery to bone marrow and tissue stores, largedose delivery, and elimination of. Check the drug label with the mar medication administration record. Additionally, iron is necessary for metabolism and synthesis of dna and various enzymatic processes. The physicians package insert for iron dextran includes a warning of the potential for injectionsite sarcoma rxlist 2010.
Do not administer iron dextran to patients with evidence of iron overload e. For endstage renal disease patients on hemodialysis, intravenous iv iron is more efficacious than oral iron. Common and rare side effects for iron dextran injection. Iron dextran may also be used for purposes not listed in this medication guide. Our infed iron dextran side effects drug center provides a comprehensive view of available drug information on. Intravaneous iron mg low molecular weight iron dextran over 60 minutes for pregnant women. Iron saccharate sucroferric oxyhydroxide or iron sucrose is used as a source of iron.
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